Symptoms of Buerger's disease may include peripheral circulation problems such as pain, coldness, numbness, color changes, and limited mobility. Diagnosis can be made through typical symptoms, physical examination findings, and imaging tests (such as angiography).

While the exact cause of Buerger's disease is not fully known, it is commonly associated with smoking. Smoking can lead to a series of harmful effects that may cause inflammation and blockage of vessel walls.